Suberoylanilide Hydroxamic Acid Reactivates HIV from Latently Infected Cells
نویسندگان
چکیده
منابع مشابه
Disruption of polycomb repressor complex-mediated gene silencing reactivates HIV-1 provirus in latently infected cells.
OBJECTIVES Persistent HIV-1 infections are characterized by a long silent infection period in resting CD4+ T cells, which allows them to escape the host immune response. Several HIV-1 latency mechanisms have been reported, but the molecular mechanism underlying polycomb repressor complex (PRC)-mediated HIV-1 latency remains poorly understood. METHODS Expression of PRC proteins in latent cells...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2009
ISSN: 0021-9258
DOI: 10.1074/jbc.m807898200